EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

CL Whitehead; TJ Kaitu'u-Lino; NK Binder; S Beard; N De Alwis; F Brownfoot; S Tong; NJ Hannan

Journal article

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

CL Whitehead, TJ Kaitu'u-Lino, NK Binder, S Beard, N De Alwis, F Brownfoot, S Tong, NJ Hannan

Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2018

DOI: 10.1016/j.preghy.2018.09.001

Abstract

Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early pregnancy. Persistent placental hypoxia is thought to trigger the release of anti-angiogenic factors into the maternal circulation leading to widespread endothelial dysfunction. Epidermal growth factor-like domain 7 (EGFL7) is a secreted angiogenic factor that may play a key role in the disrupted angiogenesis seen in response to placental hypoxia that characterizes preeclampsia. Methods: Primary trophoblasts were isolated and cultured in both normoxic and hypoxic conditions. Under hypoxia HIF1α was silenced and EGFL7 mRNA expression was assessed. EGFL7 mRNA express..

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University of Melbourne Researchers

Clare Whitehead Author

Tu'uhevaha Kaitu'u-Lino Author

Natalie Binder Author

Fiona Brownfoot Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

National Health and Medical Research Council (NHMRC) of Australia grant (#1061977, #1048707) and salary support from the NHMRC (#1050765, #1062418, #628927) and a University of Melbourne C R Roper Research Fellowship.